Early bone formation in furrows at titanium implants. A study in the rabbit tibia


Submitted: 8 June 2017
Accepted: 8 June 2017
Published: 30 March 2010
Abstract Views: 329
PDF: 555
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

  • Patricia Miranda Burgos Department of Biomaterials, Institute for Surgical Sciences, Sahlgrenska Academy at Gothenburg University, Sweden.
  • Luiz Meirelles Department of Prosthetic Dentistry, Institute of Odontology, Sahlgrenska Academy at Gothenburg University, Sweden.
  • Lars Sennerby Department of Biomaterials, Institute for Surgical Sciences, Sahlgrenska Academy at Gothenburg University, Sweden.
Aim Previous studies have shown a preference for bone formation in macroscopic furrows as compared to other parts of the implant surface. The aim of the study was to describe the early events of bone integration of furrowed oxidized titanium implants. Materials and Methods New Zealand white rabbits and 54 implants were used in the study. The test oxidized implants had a 110 μm wide furrow added to the superior flank whilst the control oxidized implants had no furrow. The implants were retrieved after 7, 14 and 28 days for light microscopy and for micro-CT evaluation. Results The bone contact and bone area values increased with time for all implants. A statistically significant preference for bone formation in the furrows was seen for test implants and for the inferior thread flank for control implants compared to the opposing superior thread flank. The 3D reconstructions from micro-CT showed bone formation as thin rims along the implant surface either continuous or as solitary rims. Conclusion It is concluded, that bone formation is observed more often at the lower flank and in macroscopic furrows at the threads than opposing upper flanks of oxidized titanium implants. This was more marked at seven days than later time points and in areas with no primary contacts with adjacent host bone. Bone integration of the implants seemed to occur by bone condensation directly at and along the implant surface and following the path of the implant threads.

Supporting Agencies


Burgos, P. M., Meirelles, L., & Sennerby, L. (2010). Early bone formation in furrows at titanium implants. A study in the rabbit tibia. Journal of Osseointegration, 2(1), 15–22. https://doi.org/10.23805/jo.2010.02.01.01

Downloads

Download data is not yet available.

Citations