Histological and histomorphometrical evaluation of two types of bone substitutes in combination with i-PRF for bone regeneration in critical bone defects: An in vivo study


Published: 22 November 2022
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Aim This study aimed to evaluate the bone regeneration performance of two types of xenografts (Bio-Oss, Geistlich Pharma AG, Wolhusen, CH; Cerabone, Institut Straumann, Basel CH) isolated and associated with i-PRF, in critical bone defects in rat calvaria. 

Materials and methods Surgical defects were performed and filled with different materials, according to the referred groups: clot (CG), autogenous bone (AG), Bio-Oss® (BO), Cerabone (CB), i-PRF homogenous (i-PRF), Bio-Oss associated with i-PRF (BOPRF) and Cerabone associated with i-PRF (CBPRF). The animals were euthanized for histological and histomorphometric analysis after 4 and 8 weeks. Statistical analysis for bone neoformation assessment was performed by ANOVA and complemented by Tukey's test. 

Results The AG group exhibited the highest mean values for bone neoformation (37.83 ± 7.96) in this study. Among the bone substitutes, CBPRF group (18.79 ± 5.98) exhibited highest means (p<0.05) compared to BO group (10.20 ± 2.82) and CG group (6.96 ± 3.29). i-PRF group (17.07 ± 4.95), BOPRF group (16.86 ± 6.14), BO group (10.20 ± 2.82), and CB group (16.15 ± 4.72) were not significant among them (p>0.05). 

Conclusions According to the results obtained in this study, it was observed that Cerabone® and Bio-Oss®, associated with i-PRF, exhibited a satisfactory applicability to fill critical defects, favoring the bone regeneration process.


Ribeiro de Albuquerque Boia, J., Soares, L. F. F., Passos, G. P., dos Santos Neves, J., Mariano, R. C., & Vital Ribeiro Junior, N. (2022). Histological and histomorphometrical evaluation of two types of bone substitutes in combination with i-PRF for bone regeneration in critical bone defects: An in vivo study. Journal of Osseointegration, 14(4), 217–225. https://doi.org/10.23805/JO.2022.14.33

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