https://doi.org/10.23805/JO.2022.14.33

Histological and histomorphometrical evaluation of two types of bone substitutes in combination with i-PRF for bone regeneration in critical bone defects: An in vivo study

Vol. 14 No. 4 (2022)
Published: 22 November 2022
Bone regeneration, bone substitutes, Platelet-Rich Fibrin (PRF)
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Authors

J. Ribeiro de Albuquerque Boia
Federal University of Alfenas, Brazil.
L. F. Ferreira Soares
https://orcid.org/0000-0003-4174-2943
Federal University of Alfenas, Brazil.
G. P. Passos
Federal University of Alfenas, Brazil.
J. dos Santos Neves
Federal University of Alfenas, Brazil.
R. Célio Mariano
Federal University of Alfenas, Brazil.
N. Vital Ribeiro Junior
noe.ribeiro@unifal-mg.edu.br
Dental School, Brazil.

Aim This study aimed to evaluate the bone regeneration performance of two types of xenografts (Bio-Oss, Geistlich Pharma AG, Wolhusen, CH; Cerabone, Institut Straumann, Basel CH) isolated and associated with i-PRF, in critical bone defects in rat calvaria. 

Materials and methods Surgical defects were performed and filled with different materials, according to the referred groups: clot (CG), autogenous bone (AG), Bio-Oss® (BO), Cerabone (CB), i-PRF homogenous (i-PRF), Bio-Oss associated with i-PRF (BOPRF) and Cerabone associated with i-PRF (CBPRF). The animals were euthanized for histological and histomorphometric analysis after 4 and 8 weeks. Statistical analysis for bone neoformation assessment was performed by ANOVA and complemented by Tukey's test. 

Results The AG group exhibited the highest mean values for bone neoformation (37.83 ± 7.96) in this study. Among the bone substitutes, CBPRF group (18.79 ± 5.98) exhibited highest means (p<0.05) compared to BO group (10.20 ± 2.82) and CG group (6.96 ± 3.29). i-PRF group (17.07 ± 4.95), BOPRF group (16.86 ± 6.14), BO group (10.20 ± 2.82), and CB group (16.15 ± 4.72) were not significant among them (p>0.05). 

Conclusions According to the results obtained in this study, it was observed that Cerabone® and Bio-Oss®, associated with i-PRF, exhibited a satisfactory applicability to fill critical defects, favoring the bone regeneration process.

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How to Cite

Ribeiro de Albuquerque Boia, J., Soares, L. F. F., Passos, G. P., dos Santos Neves, J., Mariano, R. C., & Vital Ribeiro Junior, N. (2022). Histological and histomorphometrical evaluation of two types of bone substitutes in combination with i-PRF for bone regeneration in critical bone defects: An in vivo study. Journal of Osseointegration, 14(4), 217–225. https://doi.org/10.23805/JO.2022.14.33
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