Ridge preservation with acellular dermal matrix and anorganic bone matrix cell-binding peptide P-15 after tooth extraction in humans. A histologic and morphometric study


Submitted: 8 June 2017
Accepted: 8 June 2017
Published: 30 June 2012
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Authors

  • Arthur B. Novaes Jr. DDS, MSc, PhD, Chairman of Periodontology - Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Patricia Garani Fernandes DDS, MSc, Graduate Students of Department of Oral Surgery and Periodontology - Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Flávia Adelino Suaid DDS, MSc, Graduate Students of Department of Oral Surgery and Periodontology - Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Marcio Fernando De Moraes Grisi DDS, MSc, PhD, Associate Professor of Department of Oral Surgery and Periodontology - Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Sergio Luis Scombatti De Souza DDS, MSc, PhD, Associate Professor of Department of Oral Surgery and Periodontology - Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Mario Taba Jr. DDS, MSc, PhD, Associate Professor of Department of Oral Surgery and Periodontology - Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Daniela Bazan Palioto DDS, MSc, PhD, Associate Professor of Department of Oral Surgery and Periodontology - Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Valdir Antonio Muglia DDS, MSc, PhD, Professor of Department of Dental Materials and Prosthodontics- Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
Aim The aim of this study was to analyze by histomorphometric parameters the use of acellular dermal matrix (ADM) with or without anorganic bovine bone matrix (ABM) / synthetic cell-binding peptide P-15 in the formation of bone in human alveoli. Materials and methods Eighteen patients in need of extraction of maxillary anterior teeth were selected and randomly assigned to the test group (ADM plus ABM/P-15) or the control group (ADM only). Histomorphometric measurements and histological analysis were recorded about 6 months after ridge preservation procedures in ten patients. The amount of newly formed bone, the most recently formed bone, fibrous tissue plus marrow spaces and remaining graft particles were measured and analyzed. Results At 6 months, the new bone area parameter and the percentage of fibrous tissue plus marrow space areas showed higher values to the control group, and statistically significant differences when compared with the test group (p=0.03). Conclusion The ADM acted as a membrane. The association of ABM/P-15 with ADM resulted in new bone formation within the alveoli, but the results were not considered relevant when used in this indication.

Supporting Agencies


Novaes Jr., A. B., Garani Fernandes, P., Suaid, F. A., De Moraes Grisi, M. F., Scombatti De Souza, S. L., Taba Jr., M., Bazan Palioto, D., & Muglia, V. A. (2012). Ridge preservation with acellular dermal matrix and anorganic bone matrix cell-binding peptide P-15 after tooth extraction in humans. A histologic and morphometric study. Journal of Osseointegration, 4(2), 23–30. https://doi.org/10.23805/jo.2012.04.02.01

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