The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stability


Submitted: 14 June 2017
Accepted: 14 June 2017
Published: 30 March 2013
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Authors

  • Fernando E. Kayatt Private dentist at Ponta Porã, Mato Grosso do Sul, Brazil.
  • Thallita P. Queiroz Assistant Professor, Department of Health Sciences, Implantology Post Graduation Course, Dental School, University Center of Araraquara - UNIARA, Araraquara, São Paulo, Brazil.
  • Rogério Margonar Assistant Professor, Department of Health Sciences, Implantology Post Graduation Course, Dental School, University Center of Araraquara - UNIARA, Araraquara, São Paulo, Brazil.
  • Eloá R. Luvizuto Department of Surgery and Integrated Clinic, Araçatuba Dental School, UNES P-Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
  • Idelmo R. Garcia Jr. Department of Surgery and Integrated Clinic, Araçatuba Dental School, UNES P-Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
  • Roberta Okamoto Department of Anatomy, Araçatuba Dental School, UNES P-Univ Estadual Paulista, São Paulo, Brazil.
Aim Primary implant stability can be compromised by overdrilling of the implant bed. Filling the gap between the implant and the bone with a highly viscous copolymer of polylactic and polyglycolic acid (PLA/PGA) might stabilize the implant and thus supply osseointegration. The aim of this study was to evaluate implants installed in overdrilled beds associated with PLA/PGA in rats tibia model by means of removal torque test and fluorochrome analysis. Materials and methods For this experiment two groups were selected: in the test group 0.4 mm overdrilled defects (2.0 in diameter and 3 mm long ) were produced in the right tibia of seven rats and implants were placed covered with PLA/PGA biomaterial to fill the gap; the control group was not overdrilled and the implants were placed without the biomaterial. Implants of 1.6 mm in diameter and 3 mm long where placed into all defects. Calcein, alizarin and oxytetracyclin were injected at 7, 15 and 21 postoperative days, respectively, and the animals were sacrificed at 35 postoperative day. Results The results showed that all the implants achieved osseointegration. There were no statistical significance differences in torque-reverse and fluorocrome analysis (P>0.05). Conclusion We can conclude that overdrilled defects filled with PLA/PGA did not disturb osseointegration in this experimental model.

Supporting Agencies


Kayatt, F. E., Queiroz, T. P., Margonar, R., Luvizuto, E. R., Garcia Jr., I. R., & Okamoto, R. (2013). The use of polylactic and polyglycolic copolymer biomaterial in a pre-clinical model of compromised primary stability. Journal of Osseointegration, 5(1), 3–7. https://doi.org/10.23805/jo.2013.05.01.01

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