Journal of Osseointegration <h1>Journal of Osseointegration</h1> <p>The aim of the<strong> Journal of Osseointegration</strong> in the Implant Dentistry field is to publish high quality contemporary, timely, innovative, interesting and clinically relevant information that will be used for improvement of the care of our patients. The rapid growth of research and more application of advanced clinical procedures has led us to start this new journey, that we hope will be a journey of success. The objective of all the people involved in this project will be to present the data in an accurate, fair and unbiased way. Each paper will be given the close attention that it merits and only manuscripts with well designed projects, conducted in a manner that follows sound scientific principles will be accepted. Also the rapidity of the reviewing process will be a key goal, this will be ensured by a web based submission and colse supervision on the reviewing process. A concerted effort will be made to shorten the time between submission, correction, acceptance of the manuscript, online publication, and print publication. We aim also for a high standard of technical editing, which serves to ensure the consistency of the content style and the fact that the language should be as unambiguous and clear as possible. Manuscripts dealing with basic research, biomaterials, tissue engineering techniques, clinical research and technical innovations will be accepted. The help of all involved people will be of outstanding relevance in achieving this mission.<br><em>Access to the contents of the Journal of Osseointegration is open and free to all users: this is our small contribution to global exchange of knowledge. Users can read, download, copy, distribute, print, search, or link to the full texts of our articles.</em></p> ©Ariesdue srl, Milan, Italy. Online version powered by PAGEPress Scientific Publications, Pavia, Italy en-US Journal of Osseointegration 2036-4121 <p><strong>PAGEPress</strong> has chosen to apply the&nbsp;<a href="" target="_blank" rel="noopener"><strong>Creative Commons Attribution NonCommercial 4.0 International License</strong></a>&nbsp;(CC BY-NC 4.0) to all manuscripts to be published.</p> Evaluation of implant stability and marginal bone loss in immediate implant using “nano bone” versus “autogenous bone” for the treatment of patients with unrestorable single tooth: a randomized controlled trial <p><strong>Aim</strong> A randomized controlled trial was conducted to evaluate the advantages of using nano-hydroxyapatite (nHA) bone graft compared to the "gold standard" autogenous bone graft in the jumping gap with immediate implants.<span class="Apple-converted-space">&nbsp;</span></p> <p><strong>Materials and methods</strong> Immediate implant placement was performed for the treatment of patients with an unrestorable single tooth. All eligible patients, in total 18, were randomly selected and divided in two groups, controls (AG) and study group (NB), in equal proportions (9 for eah group). Six month later implants were surgically exposed and the measurements of the secondary outcomes were taken.<span class="Apple-converted-space">&nbsp;</span></p> <p><strong>Results</strong> Implant stability outcomes showed no significant differences in the groups. Marginal bone level of both groups at baseline and after six months showed a significant difference, as<span class="Apple-converted-space">&nbsp; </span>bone loss occurred more in NB group than AG group.<span class="Apple-converted-space">&nbsp;</span></p> <p><strong>Conclusion</strong> Within the limits of the present study the placement of NB graft in the jumping gap contributed in decreasing and reduced the morbidity of the donor site compared to autogenous bone (AB) group. Trial had been registered in both The Pan African Clinical Trials Registry (PACTR) PACTR201512001348246 and clinical NCT02613663.</p> S. A. N. Adam A. E. Elarab A. R. A. Rahman D. F. Abel Rahim ##submission.copyrightStatement## 2019-10-28 2019-10-28 11 4 8 17 10.23805/JO.2019.12.01.21 Antibacterial properties and side effects of chlorhexidine-based mouthwashes. A prospective, randomized clinical study <p><strong>Aim</strong> Chlorhexidine (CHX) is commonly used in clinical applications, including plaque control and gingivitis treatment. The im of this study was to evaluate the clinical properties, in terms of plaque control, bleeding and discoloration levels, of six CHX mouthwashes that differ in the following characteristics: CHX concentration, presence/absence of alcohol and presence/absence of an anti-discoloration system (ADS).</p> <p><strong>Materials and methods</strong> A single-center, prospective, double-blind randomized clinical trial was carried out on 78 consecutive patients. Six mouthwashes (CHX 0.12% alcohol free; CHX 0.20% alcohol free; CHX 0.12% alcohol free with ADS; CHX 0.20% alcohol free with ADS; CHX 0.12% with alcohol; CHX 0.20% with alcohol) were tested. Plaque Index (PI) and Bleedind Index (BI) were recorded, along with tooth staining (spectrophotometry) at T0 (beginning), at T1 (after 7 days), at T2 (after 14 days), and T3 (after 21 days). Data obtained were subjected to statistical analysis.</p> <p><strong>Results</strong> All CHX mouthwashes significantly reduced PI (p&lt;0.0001), while only alcohol free CHX 0.20% significantly reduced BI (p&lt;0.0001). Only the CHX 0.12% with alcohol and CHX 0.20% with alcohol mouthwashes showed a significant presence of extrinsic tooth staining (p&lt;0.05).</p> <p><strong>Conclusions</strong> Within the limitations of the present study, the alcohol-free mouthwash CHX 0.20% allows a good control of the clinical indices, in particular the bleeding index.<span class="Apple-converted-space">&nbsp;</span></p> E. Polizzi G. Tetè F. Bova G. Pantaleo G. Gastaldi P. Capparè E. Gherlone ##submission.copyrightStatement## 2019-10-28 2019-10-28 11 4 2 7 10.23805/JO.2019.12.01.20 Evaluation of the health of the peri-implant tissues around immediately placed dental implants in aggressive periodontitis patients versus periodontally healthy individuals in the maxillary esthetic zone: Controlled clinical trial <p class="p1"><span class="s1"><strong>Aim </strong>To evaluate the health condition of the immediately placed dental implants in aggressive periodontitis patients compared to periodontally healthy individuals after 12 months of follow up.</span></p> <p class="p1"><span class="s1"><strong>Materials and methods</strong> Following atraumatic tooth extraction, 70 implants were placed in two study groups: Thirty-five implants replaced hopeless teeth in aggressive periodontitis patients (test group) and thirty-five implants replaced periodontally healthy unrestrorable teeth (control group).&nbsp;</span></p> <p class="p1"><span class="s1"><strong>Results </strong>After 12 months, there were no dropouts in both groups. The criteria of the health scale showed 97.17% success in the test group versus 100% in the control group. Due to peri-implant mucosistis, only 2.85% implants in the test group showed satisfactory survival rate. It was also found that 20% of the inserted implants in both groups were covered with bone during the second stage surgery. Lack of pain, mobility, exudate and suppuration with no incidence of peri-implant diseases were clearly detected in both groups indicating the success rate. There was no statistical significant difference between the results in both groups. </span></p> <p class="p1"><span class="s1"><strong>Conclusions</strong><span class="Apple-converted-space">&nbsp; </span>The current study highlights that immediate placement did not affect health and survival of the implants in aggressive periodontitis patients. Nearly equal results were reported between periodontally healthy and periodontally affected patients. Long- term follow up studies are recommended to examine the failure rate that could not be reported in the current short-term study. </span></p> N. M. Yussif A. R. Abdel Rahman M. Darhous ##submission.copyrightStatement## 2019-09-25 2019-09-25 11 4 10.23805/JO.2019.11.03.18 Is immediate implant placement advantageous for the management of aggressive periodontitis patients in maxillary esthetic zone? An update of systematic reviews <p class="p1"><span class="s1"><strong>Aim </strong>To determine the<span class="Apple-converted-space">&nbsp; </span>clinical safety, survival and success of the immediate dental implant placement in aggressive periodontitis patients.</span></p> <p class="p1"><span class="s1"><strong>Materials and methods</strong> In April 2019, Pubmed, Cochrane central database, Web of Science, Lilacs and hand search were searched with no restrictions for language, publication date or follow up period. All types of prospective studies reporting the prognosis of immediate implant placement were included. Outcomes were implant survival rate, complications during placement and postoperatively and marginal bone loss around implants.&nbsp;</span></p> <p class="p1"><span class="s1"><strong>Results</strong> After screening of the titles, abstracts and full text of the reported studies, none of those met the pre-determined inclusion criteria.</span></p> <p class="p1"><span class="s1"><strong>Conclusions </strong>There was no sufficient evidence regarding the survival rate of immediately placed dental implants in patients affected with aggressive periodontitis. Long term prospective double armed clinical studies are recommended.</span></p> N Yussif A. R. Abdel Rahman ##submission.copyrightStatement## 2019-09-19 2019-09-19 11 4 10.23805/JO.2019.11.03.19