Cyclosporine-a and bone density around titanium implants: a histometric study in rabbits

  • Celso Eduardo Sakakura | info@ariesdue.it Department of Periodontology, Barretos Dental School, Education Foundation of Barretos, FEB, Barretos, SP, Brazil.
  • Beatriz Maria Valério Lopes Department of Periodontology, Araraquara Dental School, São Paulo State University (UNESP) Araraquara, São Paulo, Brazil.
  • Rogério Margonar Department of Health Sciences, Disciplines of Periodontology, Integrated Clinic, and Implantology Post Graduation Course, Dental School, University Center of Araraquara, UNIARA, Araraquara, São Paulo, Brazil.
  • Thallita Pereira Queiroz Department of Health Sciences, Disciplines of Oral and Maxillofacial Surgery, Integrated Clinic and Implantology Post Graduation Course, Dental School, University Center of Araraquara, UNIARA, Araraquara, São Paulo, Brazil.
  • Francisco Humberto Nociti Jr. Department of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, UNICAMP, São Paulo, Brazil.
  • Elcio Marcantonio Jr. Department of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, UNICAMP, São Paulo, Brazil.

Abstract

Aim Cyclosporine A (CsA) is an immunosuppressive agent commonly used to prevent organ transplantation rejection. It has been demonstrated that CsA may negatively affect osseointegration around dental implants. Therefore, the aim of this study was to evaluate the effect of CsA administration on bone density around titanium dental implants. Materials and Methods Fourteen New Zealand rabbits were randomly divided into 2 groups with seven animals each. The test group (CsA) received daily subcutaneous injection of CsA (10mg/kg body weight) and the control group (CTL) received saline solution by the same route of administration. Three days after the beginning of immunosuppressive therapy, one machined dental implant (7.00 mm in lenght and 3.75 mm in diameter) was inserted bilaterally at the region of the tibial methaphysis. After 4 and 8 weeks the animals were sacrificed and the histometrical procedures were performed to analyse the bone density around the first four threads of the coronal part of the implant. Results A significant increase in the bone density was observed from the 4- to the 8 week-period in the control group (37.41% + 14.85 versus 58.23% + 16.38 – p < 0.01). In contrast, bone density consistently decreased in the test group overtime (46.31% + 17.38 versus 16.28 + 5.08 – p <0.05). In the 8-week period, there was a significant difference in bone density between the control and the test groups (58.23 + 16.38 eand16.28 + 5.08 – p= 0.001). Conclusion Within the limits of this study, long-term CsA administration may reduce bone density around titanium dental implants during the osseointegration process.

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Published
2011-06-30
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Keywords:
Bone Density, Cyclosporine, Dental Implants
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How to Cite
Sakakura, C. E., Lopes, B. M. V., Margonar, R., Pereira Queiroz, T., Nociti Jr., F. H., & Marcantonio Jr., E. (2011). Cyclosporine-a and bone density around titanium implants: a histometric study in rabbits. Journal of Osseointegration, 3(2), 25-29. https://doi.org/10.23805/jo.2011.03.02.01